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KMID : 0923620230230020013
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Immune Network
2023 Volume.23 No. 2 p.13 ~ p.13
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COVID-19 Therapeutics: An Update on Effective Treatments Against Infection With SARS-CoV-2 Variants
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Bill Thaddeus Padasas
Erica Espano
Kim Sang-Hyun
Song Young-Cheon
Lee Chong-Kil
Kim Jeong-Ki
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Abstract
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The coronavirus disease 2019 (COVID-19) pandemic is one of the most consequential global health crises in over a century. Since its discovery in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate into different variants and sublineages, rendering previously potent treatments and vaccines ineffective. With significant strides in clinical and pharmaceutical research, different therapeutic strategies continue to be developed. The currently available treatments can be broadly classified based on their potential targets and molecular mechanisms. Antiviral agents function by disrupting different stages of SARS-CoV-2 infection, while immune-based treatments mainly act on the human inflammatory response responsible for disease severity. In this review, we discuss some of the current treatments for COVID-19, their mode of actions, and their efficacy against variants of concern. This review highlights the need to constantly evaluate COVID-19 treatment strategies to protect high risk populations and fill in the gaps left by vaccination.
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KEYWORD
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COVID-19, Severe acute respiratory syndrome coronavirus 2, Antiviral agents, Immunotherapy, Variants
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